AustralieFrV1, Main, Exploration, bibRecord, 007262

Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models

Identifieur interne : 007262 ( Main/Exploration ); précédent : 007261; suivant : 007263

Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models

Auteurs : Kelvin K. Leung [Royaume-Uni] ; Kai-Kai Shen [Australie, France] ; Josephine Barnes [Royaume-Uni] ; Gerard R. Ridgway [Royaume-Uni] ; Matthew J. Clarkson [Royaume-Uni] ; Jurgen Fripp [Australie] ; Olivier Salvado [Australie] ; Fabrice Meriaudeau [France] ; Nick C. Fox [Royaume-Uni] ; Pierrick Bourgeat [Australie] ; Sébastien Ourselin [Royaume-Uni]

Source :

Lecture Notes in Computer Science [ 0302-9743 ] ; 2010.

RBID : ISTEX:223B88570996CDF4E0206C6323DE3E49C0E6BF61

English descriptors

Abstract

Abstract: Identifying mild cognitive impairment (MCI) subjects who will convert to clinical Alzheimer’s disease (AD) is important for therapeutic decisions, patient counselling and clinical trials. Hippocampal volume and rate of atrophy predict clinical decline at the MCI stage and progression to AD. In this paper, we create p-maps from the differences in the shape of the hippocampus between 60 normal controls and 60 AD subjects using statistical shape models, and generate different regions of interest (ROI) by thresholding the p-maps at different significance levels. We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs.

Url:

https://api.istex.fr/document/223B88570996CDF4E0206C6323DE3E49C0E6BF61/fulltext/pdf

DOI: 10.1007/978-3-642-15745-5_16

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000659
to stream Istex, to step Curation: 000659
to stream Istex, to step Checkpoint: 000B79
to stream Main, to step Merge: 007798
to stream Main, to step Curation: 007262

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models</title>
<author><name sortKey="Leung, Kelvin K" sort="Leung, Kelvin K" uniqKey="Leung K" first="Kelvin K." last="Leung">Kelvin K. Leung</name>
</author>
<author><name sortKey="Shen, Kai Kai" sort="Shen, Kai Kai" uniqKey="Shen K" first="Kai-Kai" last="Shen">Kai-Kai Shen</name>
</author>
<author><name sortKey="Barnes, Josephine" sort="Barnes, Josephine" uniqKey="Barnes J" first="Josephine" last="Barnes">Josephine Barnes</name>
</author>
<author><name sortKey="Ridgway, Gerard R" sort="Ridgway, Gerard R" uniqKey="Ridgway G" first="Gerard R." last="Ridgway">Gerard R. Ridgway</name>
</author>
<author><name sortKey="Clarkson, Matthew J" sort="Clarkson, Matthew J" uniqKey="Clarkson M" first="Matthew J." last="Clarkson">Matthew J. Clarkson</name>
</author>
<author><name sortKey="Fripp, Jurgen" sort="Fripp, Jurgen" uniqKey="Fripp J" first="Jurgen" last="Fripp">Jurgen Fripp</name>
</author>
<author><name sortKey="Salvado, Olivier" sort="Salvado, Olivier" uniqKey="Salvado O" first="Olivier" last="Salvado">Olivier Salvado</name>
</author>
<author><name sortKey="Meriaudeau, Fabrice" sort="Meriaudeau, Fabrice" uniqKey="Meriaudeau F" first="Fabrice" last="Meriaudeau">Fabrice Meriaudeau</name>
</author>
<author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name>
</author>
<author><name sortKey="Bourgeat, Pierrick" sort="Bourgeat, Pierrick" uniqKey="Bourgeat P" first="Pierrick" last="Bourgeat">Pierrick Bourgeat</name>
</author>
<author><name sortKey="Ourselin, Sebastien" sort="Ourselin, Sebastien" uniqKey="Ourselin S" first="Sébastien" last="Ourselin">Sébastien Ourselin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:223B88570996CDF4E0206C6323DE3E49C0E6BF61</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1007/978-3-642-15745-5_16</idno>
<idno type="url">https://api.istex.fr/document/223B88570996CDF4E0206C6323DE3E49C0E6BF61/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000659</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000659</idno>
<idno type="wicri:Area/Istex/Curation">000659</idno>
<idno type="wicri:Area/Istex/Checkpoint">000B79</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000B79</idno>
<idno type="wicri:doubleKey">0302-9743:2010:Leung K:increasing:power:to</idno>
<idno type="wicri:Area/Main/Merge">007798</idno>
<idno type="wicri:Area/Main/Curation">007262</idno>
<idno type="wicri:Area/Main/Exploration">007262</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models</title>
<author><name sortKey="Leung, Kelvin K" sort="Leung, Kelvin K" uniqKey="Leung K" first="Kelvin K." last="Leung">Kelvin K. Leung</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Medical Image Computing, University College London, WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shen, Kai Kai" sort="Shen, Kai Kai" uniqKey="Shen K" first="Kai-Kai" last="Shen">Kai-Kai Shen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian eHealth Research Centre, CSIRO ICT Centre</wicri:regionArea>
<wicri:noRegion>CSIRO ICT Centre</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">France</country>
<wicri:regionArea>Université de Bourgogne, Le2i UMR CNRS 5158</wicri:regionArea>
<orgName type="university">Université de Bourgogne</orgName>
<placeName><settlement type="city">Dijon</settlement>
<region type="region" nuts="2">Région Bourgogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barnes, Josephine" sort="Barnes, Josephine" uniqKey="Barnes J" first="Josephine" last="Barnes">Josephine Barnes</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ridgway, Gerard R" sort="Ridgway, Gerard R" uniqKey="Ridgway G" first="Gerard R." last="Ridgway">Gerard R. Ridgway</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Medical Image Computing, University College London, WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarkson, Matthew J" sort="Clarkson, Matthew J" uniqKey="Clarkson M" first="Matthew J." last="Clarkson">Matthew J. Clarkson</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Medical Image Computing, University College London, WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fripp, Jurgen" sort="Fripp, Jurgen" uniqKey="Fripp J" first="Jurgen" last="Fripp">Jurgen Fripp</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian eHealth Research Centre, CSIRO ICT Centre</wicri:regionArea>
<wicri:noRegion>CSIRO ICT Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvado, Olivier" sort="Salvado, Olivier" uniqKey="Salvado O" first="Olivier" last="Salvado">Olivier Salvado</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian eHealth Research Centre, CSIRO ICT Centre</wicri:regionArea>
<wicri:noRegion>CSIRO ICT Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meriaudeau, Fabrice" sort="Meriaudeau, Fabrice" uniqKey="Meriaudeau F" first="Fabrice" last="Meriaudeau">Fabrice Meriaudeau</name>
<affiliation wicri:level="4"><country xml:lang="fr">France</country>
<wicri:regionArea>Université de Bourgogne, Le2i UMR CNRS 5158</wicri:regionArea>
<orgName type="university">Université de Bourgogne</orgName>
<placeName><settlement type="city">Dijon</settlement>
<region type="region" nuts="2">Région Bourgogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bourgeat, Pierrick" sort="Bourgeat, Pierrick" uniqKey="Bourgeat P" first="Pierrick" last="Bourgeat">Pierrick Bourgeat</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian eHealth Research Centre, CSIRO ICT Centre</wicri:regionArea>
<wicri:noRegion>CSIRO ICT Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ourselin, Sebastien" sort="Ourselin, Sebastien" uniqKey="Ourselin S" first="Sébastien" last="Ourselin">Sébastien Ourselin</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Medical Image Computing, University College London, WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="s">Lecture Notes in Computer Science</title>
<imprint><date>2010</date>
</imprint>
<idno type="ISSN">0302-9743</idno>
<idno type="eISSN">1611-3349</idno>
<idno type="ISSN">0302-9743</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0302-9743</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adni</term>
<term>Adni website</term>
<term>Alzheimer disease</term>
<term>Atrophy</term>
<term>Atrophy rate</term>
<term>Atrophy rates</term>
<term>Baseline</term>
<term>Boundary shift integral</term>
<term>Clinical decline</term>
<term>Clinical trials</term>
<term>Closest point</term>
<term>Converter</term>
<term>Dementia research centre</term>
<term>Diagnostic groups</term>
<term>Disease neuroimaging initiative</term>
<term>Early diagnosis</term>
<term>Full hippocampus</term>
<term>Hippocampal</term>
<term>Hippocampal atrophy</term>
<term>Hippocampal atrophy rates</term>
<term>Hippocampal boundary region</term>
<term>Hippocampal segmentations</term>
<term>Hippocampal surface</term>
<term>Hippocampal surfaces</term>
<term>Hippocampal volume</term>
<term>Hippocampus</term>
<term>Impairment</term>
<term>Leung</term>
<term>Local atrophy</term>
<term>Local rois</term>
<term>Neuroimage</term>
<term>Normal controls</term>
<term>Right hippocampus</term>
<term>Roi</term>
<term>Segmentation</term>
<term>Stable subjects</term>
<term>Statistical power</term>
<term>Statistical shape models</term>
<term>Surface maps</term>
<term>Target surface smci</term>
<term>Therapeutic decisions</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Adni</term>
<term>Adni website</term>
<term>Alzheimer disease</term>
<term>Atrophy</term>
<term>Atrophy rate</term>
<term>Atrophy rates</term>
<term>Baseline</term>
<term>Boundary shift integral</term>
<term>Clinical decline</term>
<term>Clinical trials</term>
<term>Closest point</term>
<term>Converter</term>
<term>Dementia research centre</term>
<term>Diagnostic groups</term>
<term>Disease neuroimaging initiative</term>
<term>Early diagnosis</term>
<term>Full hippocampus</term>
<term>Hippocampal</term>
<term>Hippocampal atrophy</term>
<term>Hippocampal atrophy rates</term>
<term>Hippocampal boundary region</term>
<term>Hippocampal segmentations</term>
<term>Hippocampal surface</term>
<term>Hippocampal surfaces</term>
<term>Hippocampal volume</term>
<term>Hippocampus</term>
<term>Impairment</term>
<term>Leung</term>
<term>Local atrophy</term>
<term>Local rois</term>
<term>Neuroimage</term>
<term>Normal controls</term>
<term>Right hippocampus</term>
<term>Roi</term>
<term>Segmentation</term>
<term>Stable subjects</term>
<term>Statistical power</term>
<term>Statistical shape models</term>
<term>Surface maps</term>
<term>Target surface smci</term>
<term>Therapeutic decisions</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Identifying mild cognitive impairment (MCI) subjects who will convert to clinical Alzheimer’s disease (AD) is important for therapeutic decisions, patient counselling and clinical trials. Hippocampal volume and rate of atrophy predict clinical decline at the MCI stage and progression to AD. In this paper, we create p-maps from the differences in the shape of the hippocampus between 60 normal controls and 60 AD subjects using statistical shape models, and generate different regions of interest (ROI) by thresholding the p-maps at different significance levels. We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Région Bourgogne</li>
</region>
<settlement><li>Dijon</li>
<li>Londres</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université de Bourgogne</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Leung, Kelvin K" sort="Leung, Kelvin K" uniqKey="Leung K" first="Kelvin K." last="Leung">Kelvin K. Leung</name>
</region>
<name sortKey="Barnes, Josephine" sort="Barnes, Josephine" uniqKey="Barnes J" first="Josephine" last="Barnes">Josephine Barnes</name>
<name sortKey="Clarkson, Matthew J" sort="Clarkson, Matthew J" uniqKey="Clarkson M" first="Matthew J." last="Clarkson">Matthew J. Clarkson</name>
<name sortKey="Clarkson, Matthew J" sort="Clarkson, Matthew J" uniqKey="Clarkson M" first="Matthew J." last="Clarkson">Matthew J. Clarkson</name>
<name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name>
<name sortKey="Leung, Kelvin K" sort="Leung, Kelvin K" uniqKey="Leung K" first="Kelvin K." last="Leung">Kelvin K. Leung</name>
<name sortKey="Ourselin, Sebastien" sort="Ourselin, Sebastien" uniqKey="Ourselin S" first="Sébastien" last="Ourselin">Sébastien Ourselin</name>
<name sortKey="Ourselin, Sebastien" sort="Ourselin, Sebastien" uniqKey="Ourselin S" first="Sébastien" last="Ourselin">Sébastien Ourselin</name>
<name sortKey="Ridgway, Gerard R" sort="Ridgway, Gerard R" uniqKey="Ridgway G" first="Gerard R." last="Ridgway">Gerard R. Ridgway</name>
<name sortKey="Ridgway, Gerard R" sort="Ridgway, Gerard R" uniqKey="Ridgway G" first="Gerard R." last="Ridgway">Gerard R. Ridgway</name>
</country>
<country name="Australie"><noRegion><name sortKey="Shen, Kai Kai" sort="Shen, Kai Kai" uniqKey="Shen K" first="Kai-Kai" last="Shen">Kai-Kai Shen</name>
</noRegion>
<name sortKey="Bourgeat, Pierrick" sort="Bourgeat, Pierrick" uniqKey="Bourgeat P" first="Pierrick" last="Bourgeat">Pierrick Bourgeat</name>
<name sortKey="Fripp, Jurgen" sort="Fripp, Jurgen" uniqKey="Fripp J" first="Jurgen" last="Fripp">Jurgen Fripp</name>
<name sortKey="Salvado, Olivier" sort="Salvado, Olivier" uniqKey="Salvado O" first="Olivier" last="Salvado">Olivier Salvado</name>
</country>
<country name="France"><region name="Région Bourgogne"><name sortKey="Shen, Kai Kai" sort="Shen, Kai Kai" uniqKey="Shen K" first="Kai-Kai" last="Shen">Kai-Kai Shen</name>
</region>
<name sortKey="Meriaudeau, Fabrice" sort="Meriaudeau, Fabrice" uniqKey="Meriaudeau F" first="Fabrice" last="Meriaudeau">Fabrice Meriaudeau</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007262 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007262 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:223B88570996CDF4E0206C6323DE3E49C0E6BF61
   |texte=   Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models

Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer’s Disease Using Hippocampal Atrophy Rate and Statistical Shape Models

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri